Einfachste Möglichkeit ist:
<table border="0" cellpadding="0" cellspacing="0">
<tr>
<td>
<img name="NoRed" src="nored.gif" width="24" height="42"></td>
<td>
<img name="Home" src="home.gif" width="127" height="42" onmouseover="window.document.images['NoRed'].src='red.gif';" onmouseout="window.document.images['NoRed'].src='nored.gif';"></td>
</tr>
Gruß
Markus